Treatment with Pirfenidone for One Year Produces a Significant Reduction in Necroinflammation and Steatosis in Patients with Liver Cirrhosis
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چکیده
HCV RNA levels were measured in patients with chronic hepatitis C (Cobas Amplicor HCV Monitor v2.0). Liver biopsies were obtained at baseline and after 12 months of treatment and were read independently by two hepatopathologists who were blinded to the biopsy sequence. Modified Histological Activity (HAI) Index of Knodell and Ishak fibrosis stage were used to assess changes in necroinflammatory scores and fibrosis stage, respectively. Change in steatosis was also assessed.
منابع مشابه
Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C
BACKGROUND The aim of this study was to assess whether two-years treatment with Pirfenidone influences necroinflammation, fibrosis and steatosis, serum levels of TGF-β1, IL-6, TNF-α and CB1 and CB2 gene expression, in patients with chronic hepatitis C (CHC). METHODS Twenty-eight patients out of 34 with CHC virus infection were enrolled in the study and received Pirfenidone (1200 mg/day) for 2...
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تاریخ انتشار 2003